Miklós Sahin-Tóth Selected Research

Trypsinogen

3/2022	Chronic progression of cerulein-induced acute pancreatitis in trypsinogen mutant mice.
1/2022	Risk of chronic pancreatitis in carriers of loss-of-function CTRC variants: A meta-analysis.
1/2022	Rate of Autoactivation Determines Pancreatitis Phenotype in Trypsinogen Mutant Mice.
1/2022	Hereditary Pancreatitis-25 Years of an Evolving Paradigm: Frank Brooks Memorial Lecture 2021.
12/2021	Evolutionary expansion of polyaspartate motif in the activation peptide of mouse cationic trypsinogen limits autoactivation and protects against pancreatitis.
1/2020	Mutation That Promotes Activation of Trypsinogen Increases Severity of Secretagogue-Induced Pancreatitis in Mice.
1/2019	Natural single-nucleotide deletion in chymotrypsinogen C gene increases severity of secretagogue-induced pancreatitis in C57BL/6 mice.
1/2019	Genetics, Cell Biology, and Pathophysiology of Pancreatitis.
1/2019	Novel Pathogenic PRSS1 Variant p.Glu190Lys in a Case of Chronic Pancreatitis.
11/2018	A preclinical model of chronic pancreatitis driven by trypsinogen autoactivation.

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Miklós Sahin-Tóth Research Topics

Disease

51	Chronic Pancreatitis 09/2022 - 11/2003
45	Pancreatitis 03/2022 - 06/2002
27	Hereditary pancreatitis 03/2022 - 02/2002
4	Autolysis 01/2020 - 07/2007
3	Pancreatic Neoplasms (Pancreatic Cancer) 01/2017 - 05/2003
2	Necrosis 03/2021 - 11/2018
2	Edema (Dropsy) 01/2020 - 11/2018
2	Cystic Fibrosis (Mucoviscidosis) 01/2016 - 02/2015
2	Neoplasms (Cancer) 11/2015 - 02/2015
2	Autoimmune Pancreatitis 02/2015 - 09/2010
2	Pancreatic Diseases (Pancreatic Disease) 08/2006 - 05/2003
1	Chronic Disease (Chronic Diseases) 03/2022
1	Seizures (Absence Seizure) 01/2020
1	Alcoholic Pancreatitis 01/2020
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2019
1	Atherosclerosis 01/2019
1	Gallstones (Gallstone) 01/2019
1	Insulin Resistance 01/2019
1	Genetic Predisposition to Disease (Genetic Predisposition) 01/2019
1	Fibrosis (Cirrhosis) 11/2018
1	Pain (Aches) 03/2018
1	Adenocarcinoma 04/2016
1	Abdominal Pain (Pain, Abdominal) 01/2016
1	Ovarian Neoplasms (Ovarian Cancer) 11/2015
1	Rare Diseases (Rare Disease) 02/2015
1	Ganglion Cysts (Ganglion) 11/2006
1	Alcoholism (Alcohol Abuse) 05/2003

Drug/Important Bio-Agent (IBA)

44	TrypsinogenIBA 03/2022 - 02/2002
25	TrypsinIBA 03/2022 - 02/2002
15	EnzymesIBA 09/2022 - 01/2008
13	chymotrypsin CIBA 01/2022 - 04/2006
13	Peptide Hydrolases (Proteases)FDA Link 01/2022 - 01/2008
12	Kazal Pancreatic Trypsin InhibitorIBA 03/2021 - 01/2005
8	CeruletideIBA 03/2022 - 02/2010
7	Chymotrypsin FDA Link 09/2022 - 12/2016
7	Protein Isoforms (Isoforms)IBA 03/2022 - 05/2003
7	Peptides (Polypeptides)IBA 12/2021 - 11/2003
6	Carboxypeptidases A (Carboxypeptidase A)IBA 01/2022 - 10/2013
6	Proteins (Proteins, Gene)FDA Link 01/2022 - 05/2009
5	Serine Proteases (Serine Protease)IBA 01/2020 - 04/2005
3	Amylases FDA Link 03/2021 - 11/2018
3	SecretagoguesIBA 01/2020 - 10/2018
3	NucleotidesIBA 01/2019 - 05/2011
3	chymotrypsinogen CIBA 01/2019 - 04/2006
3	Cathepsin BIBA 10/2018 - 06/2002
3	Amino Acids FDA Link 12/2016 - 02/2002
2	Pancreatic Elastase (Elastase)IBA 09/2022 - 01/2019
2	Ethanol (Ethyl Alcohol)IBA 01/2020 - 02/2015
2	Trypsin InhibitorsIBA 01/2020 - 07/2005
2	Protease Inhibitors (Protease Inhibitor)IBA 01/2019 - 10/2018
2	Enzyme Precursors (Zymogens)IBA 04/2006 - 05/2003
1	Transcription Factors (Transcription Factor)IBA 01/2022
1	polyaspartateIBA 12/2021
1	Aspartic Acid (Aspartate)FDA Link 12/2021
1	Calcium-Sensing ReceptorsIBA 10/2021
1	Peroxidase (Myeloperoxidase)IBA 01/2020
1	Carrier Proteins (Binding Protein)IBA 01/2020
1	Caseins (Casein)FDA Link 01/2020
1	Immunoglobulin Heavy Chains (Immunoglobulin Heavy Chain)IBA 01/2020
1	Messenger RNA (mRNA)IBA 01/2020
1	Chymases (Chymase)IBA 01/2020
1	Insulin (Novolin)FDA Link 01/2019
1	Lipase (Acid Lipase)FDA Link 01/2019
1	ChymotrypsinogenIBA 10/2018
1	erucylphosphocholineIBA 03/2018
1	pancreatic lipase related protein 2IBA 01/2018
1	trypsinogen activation peptideIBA 12/2017
1	DisulfidesIBA 06/2016
1	Biomarkers (Surrogate Marker)IBA 04/2016
1	Cholecystokinin B ReceptorIBA 04/2016
1	Bile Acids and Salts (Bile Acids)IBA 01/2016
1	Ion Channels (Ion Channel)IBA 01/2016
1	ErbB Receptors (EGF Receptor)IBA 11/2015
1	CarboxypeptidasesIBA 10/2015
1	Bicarbonates (Hydrogen Carbonate)IBA 09/2015
1	AnionsIBA 09/2015
1	Cystic Fibrosis Transmembrane Conductance Regulator (Protein, CFTR)IBA 02/2015
1	Fatty Acids (Saturated Fatty Acids)IBA 02/2015
1	ChloridesIBA 02/2015
1	RNA Precursors (Precursor, mRNA)IBA 05/2014
1	Phenobarbital (Luminal)FDA Link 12/2011
1	RNA (Ribonucleic Acid)IBA 09/2010
1	AutoantibodiesIBA 09/2010
1	Dexamethasone (Maxidex)FDA LinkGeneric 03/2010
1	Cathepsin LIBA 02/2010
1	Taurocholic Acid (Sodium Taurocholate)IBA 02/2010
1	LectinsIBA 05/2009
1	Pancreatitis-Associated ProteinsIBA 05/2009
1	Protein Sorting Signals (Signal Peptide)IBA 05/2007
1	Retinaldehyde (Retinal)IBA 11/2006
1	Codon (Codons)IBA 06/2006
1	Cysteine Proteases (Cysteine Protease)IBA 06/2002

Therapy/Procedure

6	Therapeutics 01/2019 - 02/2015
2	Injections 03/2022 - 01/2020
2	Cholecystectomy 01/2019 - 02/2015
2	Endoscopic Sphincterotomy 01/2019 - 02/2015
1	Conservative Treatment 02/2015
1	Critical Care (Surgical Intensive Care) 02/2015
1	Fluid Therapy (Oral Rehydration Therapy) 02/2015